Pipelle for Pregnancy (PIP): study protocols for three randomised controlled trials

Pipelle for Pregnancy (PIP): study protocols for three randomised controlled trials.

BACKGROUND The success rate of infertility treatments remains modest. Endometrial injury has been suggested as an intervention to increase the probability of pregnancy in women undergoing assisted reproductive technologies such as in vitro fertilisation (IVF). The majority of studies and systematic reviews have reported that endometrial injury improves the outcomes of IVF, intrauterine insemina...

Acupuncture for dyspepsia in pregnancy: a prospective, randomised, controlled study.

OBJECTIVES This study was undertaken to describe under real-life conditions the effects of acupuncture on symptomatic dyspepsia during pregnancy and to compare this with a group of patients undergoing conventional treatment alone. METHODS A total of 42 conventionally treated pregnant women were allocated by chance into two groups to be treated, or not, by acupuncture. They reported the severi...

Need for expertise based randomised controlled trials.

Covariance modelling for randomised controlled trials

The setting of interest is that of longitudinal randomized controlled clinical trials. The question of interest is: why is it that trialists think that intervention affects the mean but not the covariance structure? Trial design and execution should be a multi-criteria activity (based on joint mean-covariance modelling) and not merely focussed on the mean (location) which, curiously, is how mos...

Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications

Objective To investigate the planning of subgroup analyses in protocols of randomised controlled trials and the agreement with corresponding full journal publications. DesignCohort of protocols of randomised controlled trial and subsequent full journal publications. Setting Six research ethics committees in Switzerland, Germany, and Canada. Data sources 894 protocols of randomised controlled tr...